Sandell Lab

Linda Sandell

Linda Sandell, Ph.D

Mildred B. Simon Research Professor and Director of Research

Director, Center for Musculoskeletal Research

Department of Orthopaedic Surgery, Washington University

sandelll@wustl.edu
BJC - Institute of Health
11th floor - RM 11617
Phone: (314) 454-7800

Overview

Dr. Sandell’s laboratory focuses on gene regulation of extracellular matrix proteins and its influence on the phenotype of cells. Of particular interest is the role of transcriptional and post-transcriptional mechanisms of regulation of protein expression in the differentiation of mesenchymal cell phenotypes such as cartilage, bone, muscle and adipose. The Sandell laboratory has also had a long-standing interest in cellular mechanisms associated with chondrogenesis and endochondral bone formation and the discovery of new related extracellular matrix proteins and the interplay of positive and negative factors that regulate their expression. These anabolic and catabolic control mechanisms are of direct concern to the current understanding of the major cartilage disease, osteoarthritis. Arising from our interest in cartilage, recent studies have focused on understanding the molecular basis of inhibition of angiogenesis and tumors invasion in cartilage and the application of these findings to cancer and other diseases where neo-vascularization must be inhibited.


Mildred B Simon Research Professorship awarded to Dr. Sandell


Osteoarthritis Research Society International installs Linda Sandell as President
Linda Sandell, PhD, was installed as the president of the Osteoarthritis Research Society International at the 2010 meeting in Brussels. Dr. Sandell served as president from September 2010 until April 2013.
The Osteoarthritis Research Society International (OARSI) is the premier international organization for scientists and health care professionals focused on the prevention and treatment of osteoarthritis through the promotion and presentation of research, education and the worldwide dissemination of new knowledge.


Recent Awards

OARSI 2016 - Lifetime Achievement Award
ORS 2016 - Distinguished Investigator Award
2015 - Alfred Shands Award
2014-2019 - Editor in Chief, Journal Orthopaedic Research
2014 - Medical/Research Honoree, Arthritis Foundation Silver Ball
Winners NIRA Awards (ORS 2011)
  • Shingo Hashimoto, MD, PhD Co-Authors: Muhammad Farooq Rai, James Cheverud, Linda J Sandell
    Washington University School of Medicine, St. Louis, MO
    Osteoarthritis is associated with specific region of mouse genome
    Contributions Provided by MTF (Musculoskeletal Transplant Foundation)
  • M. Farooq Rai, PhD Co-Authors: Shingo Hashimoto, James Cheverud, Linda J Sandell
    Washington University School of Medicine, St. Louis, MO
    Specific regions of genome contribute to articular cartilage regeneration in mice
    Sponsored by the American Geriatrics Society

News

"No Pills Yet..." NIH Medline Plus article
"Obesity, aging genes may play role in arthritis."
"Genes that promote cartilage healing protect against arthritis."