Abu-Amer Lab

Yousef Abu-Amer, Ph.D

Professor

Department of Orthopaedics Washington University

abuamery@wustl.edu
BJC - Institute of Health 
11th floor - RM 11614
Phone: (314) 362-8597    

Grants

CURRENT:

ABU_AMER (PI)
7/1/2015 - 6/30/2020
NIH/NIAMS - 2 R01 AR049192
Regulatory Mechanisms of Implant-Induced Osteolysis.
This project will investigate paracrine and autocrine mechanism(s) by which PMMA particles target lymphocytes to enhance myelo-proliferation and increase osteoclast burden and osteolysis.

ABU_AMER (PI)
4/1/13-3/31/18
NIH/NIAMS - 5R01-AR054326-07
Molecular Mechanisms Underlying Tak1 Function in Osteoclasts
Goal: Delineate the mechanism(s) governing TAK1 signaling during osteoclastogenesis.


COMPLETED

Abu-Amer (PI)
7/1/10-6/30/15
NIH/NIAMS - 5R01-AR049192-10
Regulatory Mechanisms of implant-induced osteolysis
Goal: Outline the contribution of NF-kB signal transduction pathways and poly-ubiquitination during inflammatory osteolysis  

Abu-Amer (PI)
1/1/2012 – 12/31/2015
Biomedical Research Grant#85600
Shriners Hospital for Children
Mechanisms of bone loss associated with immune-inflammatory diseases.
Goal: Investigate the mechanism underlying bone erosion in scurfy mice and the role of NEMO/NF-kB.

Abu-Amer (PI)
7/1/08-3/31/13
NIH/NIAMS - R01-AR054326-05
Mechanisms of IKK regulation of basal and inflammatory osteoclastogenesis
Goals: determine the molecular role of IKK1 and IKK2 in basal and inflammatory osteoclastogenesis, and regulation of IKK activity in inflammatory osteolysis

Abu-Amer (PI)
1/1/08 – 12/31/11
Biomedical Research Grant#85100
Agency: Shriners Hospital for Children
Regulation of bone erosion relevant to JRA

Abu-Amer (PI)
3/1/04-2/28/09 (NCE: 2/28/10)
NIH/NIAMS -R01-AR049192
Regulatory Mechanisms of implant-induced osteolysis

Abu-Amer (PI)
1/1/07-12/31/09
Biomedical Research Grant #8570
Agency: Shriners Hospital for Children
Regulation of Erosive Inflammatory Arthritis by IKKs

Abu-Amer (Co-Investigator)
09/1/06-8/30/10
NIH/NIAMS - R01 AR052921
Regulatory Pathways in Osteoclast Formation and Function.

Abu-Amer (PI)
7/1/02-6/30/06(07)
NIH/NIAMS - R01-AR047443
Regulatory Mechanisms of inflammatory osteolysis.

Abu-Amer (Mentor)
7/1/05-6/30/08
Orthopedics Research Education Foundation
AAOS
Molecular role of RANKL in osteolysis.

Abu-Amer (PI)
1/1/05-12/31/07
Shriners Hospital for Children
Biomedical Research Grant #8520
Regulation of bone erosion relevant to JRA

Abu-Amer (Co-Investigator)
7/1/01-6/30/06
NIH/NIAMS - R01-AR047867
Response of the osteoporotic skeleton to in vivo loading

Abu-Amer (PI)
8/1/99 - 07/30/04
NIH/NIAMS - R01-DE 13754
Mechanisms of TNF Receptor-Mediated Osteoclastogenesis.

Abu-Amer (PI)
8/1/99 - 07/30/04
Arthritis Foundation Young Investigator Award
Arthritis Foundation
Molecular Mechanisms of TNF-Induced Inflammatory Osteolysis.

Abu-Amer (PI)
1/1/02-12/31/04
Biomedical Research Grant #8510
Shriners Hospital for Children  
Regulation of bone erosion relevant to JRA

Abu-Amer (Co-Ivestigator)
7/1/00 -6/30/03
NIH/NIAMS - R03 AR47096
Molecular Mechanisms of Implant Osteolysis
 

Abu-Amer (PI)
1999-2000
Basic Science Award
Monsanto/Searle/Washington Univ.
The role of TNF in osteoclastogenesis and osteolysis