Faccio Lab

Roberta Faccio

Roberta Faccio, Ph.D

Professor

Department of Orthopaedics Washington University

faccior@wustl.edu
BJC - Institute of Health
11th floor - RM 11615
Phone: (314) 747-4602 

Grants

ONGOING RESEARCH SUPPORT

FACCIO(PI)
09/20/2006-8/31/16
NIH/NIAMS - 2R01AR053628
Regulatory pathways in osteoclasts and immune cells
The major goals of the project is to determine the role of DAG-mediated signaling  in osteoclasts, neutrophils and dendritic cells in the context of inflammatory arthritis. 

FACCIO(Co-Investigator)
7/01/2015-6/30/16
Alvin J. Siteman Cancer Research Fund
Targeting the Bone Microenvironment in Cancer Metastasis
The goal of this study is to target the p38 pathway in bone metastases.

FACCIO(PI)
1/01/2015-12/31/19
Shriners Hospitals for Children #85100
Role of TMEM178 in macrophage activation and bone erosion in inflammatory arthritis
The goal of this study is to examine mechanisms of macrophage activation and osteoclast functions using models of arthritis.

FACCIO(PI)
4/13/2015-3/31/20
NIH/NIAMS - R01AR066551
Novel regulators of inflammatory arthritis and bone erosion
The goal of this study is to examine M1 macrophage inflammatory reactions through calcium signaling in systemic Juvenile arthritis.

FACCIO(Co-Investigator)
7/25/2003-2/29/20
NIH/NIAMS - R01 AR050211
Osteogenic and Angiogenic Response to Skeletal Loading
The Project Goals are to determine the mechano-biological pathways that lead to bone formation after mechanical loading.

FACCIO(Co-Investigator)
1/01/2016-12/31/17
Siteman Investment Program - Pre-SPORE/Pre-PPG
Tumor Environment Regulation of Metastasis
Main goal: to better understand the metastatic process in order to develop effective ways to prevent and treat the spread of breast cancer.

 

COMPLETED RESEARCH SUPPORT

FACCIO (PI)
01/01/11-12/31/14
Shriners Hospital
Role of PKCdelta in osteoclasts and immune cells
The major goals of the project is to determine the role of PKCdelta-mediated signaling in osteoclasts, neutrophils and dendritic cells in the context of inflammatory bone loss.

FACCIO (PI)
07/01/010-06/30/12
Arthritis Foundation - Arthritis Investigator
Role of PLCγ2 in juvenile arthritis
The major goals of this project are to determine the role of PLCγ2 in macrophage activation syndrome a lethal complication of juvenile arthritis.  
Role: PI

FACCIO (PI)
05/01/05 – 04/30/07
ASBMR Career Enhancement Award
Inhibition of osteolytic lesions due to breast cancer by mutein RANKL R223A
The major goal of this project is to identify the role of the mutated form of RANKL in an in vivo model of breast cancer.

FACCIO (PI)
07/01/08-06/30/10
Arthritis Foundation - Arthritis Investigator Award
Role of PLCγ2 in rheumatoid arthritis
The major goals of this project are to determine the role of PLCγ2 in the development of inflammation and bone erosion during inflammatory arthritis.

FACCIO (PI)
07/01/08-06/30/10
Arthritis Foundation - Arthritis Investigator Award, Renewal
Role of PLCγ2 in rheumatoid arthritis
The major goals of this project are to analyze development of inflammation and bone erosion in PLCγ2-/- mice during arthritis. In particular the project focuses on the role of PLCγ2 in B cell-mediated inflammatory responses during arthritis. Furthermore, we also aim to determine the in vivo anti-inflammatory effect of a PLCγ2 blocking peptide encompassing the two SH2 domains of the protein during arthritis.

FACCIO (PI)
09/01/06-08/31/10
NIH/NIAMS - R01 AR 52921
Regulatory mechanisms of osteoclast differentiation and function
The major goals of the project are to generate PLCγ2 mutants to clarify the role of the catalytic activity and the adapter function of PLCγ2 during regulation of OC differentiation using in vivo and in vitro models.

FACCIO (PI)
09/25/09-08/24/10
NIH/NIAMS - Supplement 3R01AR053628-04S1
Regulatory mechanisms of osteoclast differentiation and function
The major goal of this project is to analyze the role of PLCγ2 in dendritic cell function.

FACCIO (PI)
02/01/09-1/31/11
MD-II-2009-179 Children Discovery Institute
Novel Integrin/PLCgamma2/NF-kB Pathway in Neutrophils During Arthritis
The major goals for this project are to characterized the role of PLCγ2 in Nf function; 2) identify the PLCγ2 signaling complex by Mass Spectrometry; 3) determine key NF-κB target genes induced by integrin-mediated adhesion in WT and PLCγ2-/- neutrophils.