Sandell Lab
Mildred B. Simon Research Professor and Director of Research Department of Orthopaedic Surgery, Washington University sandelll@wustl.edu BJC - Institute of Health 11th floor - RM 11617 Phone: (314) 454-7800
CURRENT RESEARCH SUPPORT R01 AR 050847 Sandell (PI) 09/01/2007 – 08/31/2012 NIH/NIAMS “Cis Regulatory Motifs in Adult Articular Chondrocytes” This grant investigates the molecular basis for the severe chondrodysplasia caused by the lack of the enzyme Site-1-protease in cartilage and the lack of endochondral bone formation. R01 AR 050847-S1 Sandell (PI) 06/4/2010 – 08/31/2012 NIH/NIAMS “Cis Regulatory Motifs in Adult Articular Chondrocytes” This supplement is for the support of a minority college student. R01 AR 05554 Sandell (PI) 04/01/2009 - 03/31/2014 NIH/NIAMS “Function and Regulation of CD-RAP” The specific aims of this study are to: 1) determine the mechanism of the CD-RAP 183-bp regulatory domain that confers tissue specificity; 2) determine the role of additional negative/positive regulatory elements; 3) screen for and analyze co-regulators; 4) computational identification and functional validation of novel regulatory motifs. U13 AR057296 Sandell (PI) 04/01/2009 - 03/31/2013 NIH/NIAMS “Biomarkers for Osteoarthritis” The goal of this project is to support the continuation of the very successful set of meetings of the OA Biomarkers Network. This is funded for three meetings over five years. P30 AR057235 Sandell (PI) 04/01/2009 - 03/31/2014 NIH/NIAMS “Core Center for Musculoskeletal Diseases” The goal of this project is to develop a Core Center in Musculoskeletal Disease at Washington University to bring together a substantial group of investigators from our large University complex to form an identifiable unit in the research community: Research in Musculoskeletal Diseases. R01 DK065789-06A1 Long (PI); Sandell (Co-Investigator) 12/01/2008 – 11/30/2013 NIH/NIDDK “Indian Hedgehog Signaling in Osteoblast Differentiation” The main goal of this project is to understand the mechanism by which Ihh regulates the osteoblast lineage. Brophy (PI) ); Sandell (Co-Investigator) 07/01/2011 – 06/30/2012 OREF Young Investigator Grant “Metabolic Activity of the Meniscus: Potential Marker for and Predictor of Osteoarthritis” The goal of this project is to measure the metabolic activity of the meniscus with known candidate genes and start to assess the relationship of meniscal activity to patient age, chondrosis and serum biomarkers.