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Guilak Lab

Farshid Guilak

Farshid Guilak, Ph.D

Mildred B Simon Research Professor of Orthopaedic Surgery

Department of Orthopaedics Washington University

Grants

ONGOING RESEARCH SUPPORT

Guilak(PI)
4/08/2008-3/31/17
NIH/NIA - R01 AG015768
Viscoelastic Properties of Normal and OA Chondrons
The goal of this study is to determine the mechanical properties of the pericellular matrix of articular chondrocytes using micropipette aspiration and microindentation techniques.

Guilak(PI)
4/01/11 – 3/31/16
AO Foundation
Multifunctional 3D Woven Scaffolds for Osteochondral Repair
The goal of this project is to use a custom-designed 3D woven scaffold that possesses biomimetic properties of articular cartilage to develop a composite scaffold that will promote the differentiation of two tissue layers (cartilage and bone) from one population of stem cells using locally functionalized growth factors.

Guilak(PI)
9/30/12 – 9/29/16
W81XWH-12-1-0623
Assessment of Biomarkers Associated with Joint Injury and Subsequent Post-Traumatic Arthritis
The goals of this study are to measure biomarkers of osteoarthritis following articular fracture in the mouse.

Guilak(PI)
9/01/13 – 8/31/16
The Nancy Taylor Foundation
Designer Stem Cells for Treating Chronic Diseases
The goal of this project is to create a unique, customized cell type that can sense and respond to its biochemical environment in a pre-programmed way to provide long-term therapy for chronic diseases.

Guilak(PI)
9/30/13 – 7/31/18
NIH - R01 AG046927
Obesity, Biomechanics, and Inflammation in Osteoarthritis
The goal of this project is to examine the influence of dietary fatty acids on obesity-associated OA in mice, and to examine their interaction with altered biomechanical and pro-inflammatory cytokines using various in vivo and in vitro models.

Guilak(PI)
5/01/14 – 4/30/19
Arthritis Foundation - #6462
Engineering New Biological Therapies for Arthritis
The goal of this study is to expand the scope of ongoing research by incorporating cutting edge techniques in gene therapy and genome editing.

Guilak(Co-Investigator)
4/01/14 – 3/31/16
NIH
Genome Editing of Stem Cells for Analysis of Osteoarthritis Causal Variants
The goal of this study is to develop a novel in vitro system for studying the functional effect of identified OA causal variants on the biochemical and mechanical properties of articular cartilage using genome editing of induced pluripotent stem cells (iPSCs) and cartilage tissue engineering.

Guilak(Co-Investigator)
6/01/14 – 5/31/16
NIH/NIAMS - R21 AR065653
Engineering Cartilage Mechanotransduction for Treatment of Chondrocyte Injury
The goal of this study is to deconstruct mechanosensitive signaling in primary chondrocytes to better understand the basic mechanism and to provide insight for more rational therapies of joint-loading induced injuries, including osteoarthritis.

Guilak(Co-Investigator)
7/01/14 – 6/30/16
NIH/NIAMS - R03 EB017886-01A1
Probing the Bioeffects of Cavitation at Single-Cell Level
The goal of this study is to demonstrate the feasibility in constructing an experimental system and developing associated technologies for assessing the bioeffects produced by cavitation bubbles at the single-cell level.

Guilak(PI)
9/01/14 – 8/31/16
NSF - CMMI-1445792
Regulation of Cartilage Mechanobiology by Hydrostatic Pressure
The goal of this study is to elucidate the mechanism of hydrostatic pressure signal transduction in chondrocytes and in chondrogenesis.

Guilak(Co-Investigator)
12/01/14 – 11/30/16
R21
Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues
The goal of this study is to generate osteochondral tissues with human mesenchymal stem cells through spatially controlled gene transfer of differentiation factors.