Tang Lab

Simon Tang, Ph.D

Assistant Professor

Department of Orthopaedics Washington University

BJC - Institute of Health 
11th floor - RM 11621          
Phone: (314) 286-2664



R21 AR069804-01A1 (Tang)
02/01/2017 – 01/31/2019
Role: Principal Investigator
Effects of Ages and Rage on IVD Degeneration and Inflammation
The goal of this project is to examine the inflammatory effects of advanced glycation end-products, and its associated ligand, the receptor-for-advanced glycation end-products, on intervertebral disc degeneration.


K01 AR069116-01A1 (Tang)
07/01/2016 – 06/30/2020
Role: Principal Investigator
Tissue Level Deformations of the Loaded Spine in Humans with Low Back Pain
The goal of this project is to examine the in vivo structural- and material- level changes in the intervertebral disc in humans who that develop low back pain during standing.


AOTNA Research Grant (Avery/Tang)
Role: Co- Principal Investigator
Biomechanical and biological modulation to strengthen the patellar tendon augmentation
In this project we examine novel ways to mechanical enhance the repair strength and range of motion in patellar fractures using cadaver models.


P30 AR057235 (Sandell)
04/01/2014 – 03/31/2019
Role: Assoc. Director of Core B
Center for Musculoskeletal Research and Medicine
Dr. Tang co-directs Core B, which supports evaluation of musculoskeletal structure and strength in animal models.


R21 AR067958 (Silva)
04/01/2015 – 03/31/2017
Role: Co-Investigator
An Improved Stress Fracture Model to Study Drug Effects on Bone Damage Repair
The goal of this project is to develop a novel stress fracture model with features of an atypical femur fracture.


Completed Grants

AOTNA Research Grant (Black/Tang)
Role: Co- Principal Investigator
Comparison of novel patellar tendon augmentation techniques to maximize strength
The aim of this project was to develop a system to simultaneously determine the strength of repaired patellar tendons in real time during functionally relevant loading situations.


RUI 1105310  (Vierra/Tang/et al)
07/1/2011- 06/30/2014
National Science Foundation (Eng) – University of the Pacific.
Role: Co- Principal Investigator.
The Molecular Mechanisms and Mechanical Behavior of Glue Silks from Black Widows
This project investigates the relationship between the molecular structure and mechanical behavior of spider glue silks, a class of fibers spun from newly discovered glue silk proteins.


R43- AG060607 (Hansma/Tang)
National Institute of Aging
Role: Co-Principal Investigator
A bone quality diagnostic instrument for the improved assessment of fracture risk
This current proposal examines the feasibility and the overall systematic predictive capability of a new instrumental for the clinical diagnostic of fracture assessment by direct and minimally invasive indentation.


F32-AR059497 (Tang)
NIAMS Ruth L. Kirschstein Postdoc Fellowship (F32)
The Role of MMP-13 in the TGF-beta Regulation of Bone Matrix Material Properties
The research work proposed here aims to address the mechanisms of matrix metalloproteinase-13 in the TGF-2 regulation of bone matrix material properties would allow the precise manipulation of the regulatory processes of healthy bone maintenance.


Breakthrough Biomedical Research
Sandler Family Foundation via UCSF
Role: Principal Investigator
A Novel Therapy for the Nonenzymatic Glycation Mediated Effects of Degeneration in the Intervertebral Disc


Tissue Acquisition Grant (Tang)
07/01/2010 – 06/30/2011
Musculoskeletal Transplant Foundation
Role: PI
MTF Tissue donation
The Influence of Nonenzymatic Glycation on the Tissue Material Properties and Diffusion Mechanics of the Intervertebral Disc


Arthritis Foundation Postdoc Fellowship – Arthritis Foundation
Awarded: 06/2010.
Role: PI (Declined to accept F32 award at UCSF)
The Role of MMP-13 in the TGF-beta Mediated Pathogenesis of Osteoarthritis


NIST/NRC Postdoctoral Fellowship – National Institutes of Standards and Technology/National Research Council.
Awarded: 08/2007.
Role: PI (Declined to accept postdoc position at UCSF)
Combinatorial Methods for the Rapid Screening of Novel Biomaterials


Trainee Grants

T32 EB018266 (Predoc Mentee: Christian Weber)
Role: Mentor/Preceptor
Interdisciplinary Training in Mechanobiology from nm to cm (MBnc)

T32 AR060719 (Postdoc Mentee: Adam Abraham)
Role: Mentor/Preceptor
Metabolic Skeletal Disorders Training Program Grant