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O'Keefe Lab

Simon Tang

Regis O'Keefe, MD, Ph.D

Chairman, Department of Orthopaedic Surgery
Professor, Orthopaedic Surgery

Department of Orthopaedics Washington University

Campus Box 8233
660 Euclid Ave
St. Louis, MO 63110
Phone: (314) 747-8414

Grants

ONGOING RESEARCH SUPPORT

O'KEEFE(PI)
11/26/14-11/25/16
Amgen
“DKK1-Ab Regulation of the Stem Cell Responses to Skeletal Injury”
The goal of this study is to define the ability of anti-DKK1 antibody to increase periosteal stem cell proliferation and differentiation, examine the expression of DKK1 in the COX2 KO model of delayed fracture healing and to define the impact of anti-DKK-1 antibody on fracture healing in the COX-2 KO model of delayed healing.

O'KEEFE(Co-Investigator)
8/15/06-7/31/17
NIH/NIAMS
“Translating Molecular Signal Pathways to Orthopaedic Trauma Care-Administrative Core”
The role of this Core is overall integration and coordination of the research Projects and the Molecular Anatomic Core.

O'KEEFE(Co-Investigator)
8/01/15-7/31/16
NIH/NIAMS
“Translating Molecular Signal Pathways to Orthopaedic Trauma Care-Project 2”
The goals of this project are to establish Wnt/β catenin as a key mediator of PTTH effects on periosteum and defining the signals downstream of PTH involved in periosteal bone formation.

O'KEEFE(PI)
7/1/15-6/3016
Barnes-Jewish Hospital Foundation
“Orthopedic Education ”
This funding supports the International Microsurgical Training Fellowship. The goal of this fellowship experience is to give fellows, who will, for the year of his/her fellowship, responsibility for the care of patients in need of microsurgical reconstruction of their upper extremities following trauma, tumor or infection in southern India at Ganga Hospital.

O'KEEFE(PI)
04/01/16-03/31/21
NIH/NIAMS - R01AR069605
“Epigenetic Regulation in Cartilage Tissue”
The goals of this program are to elucidate novel epigenetic-regulated pathways in chondrocytes and to identify new targets to control cartilage homeostasis.